聶瑾芳，漢族，1983年出生于湖南。博士/博士后，教授，碩士研究生導(dǎo)師
研究領(lǐng)域：化學(xué)生物傳感、化學(xué)計(jì)量學(xué)。E-mail：god78@163.com；Niejinfang@glut.edu.cn。
（一）教育與工作經(jīng)歷
2011.03-至今：桂林理工大學(xué)，化學(xué)與生物工程學(xué)院，副教授（2012）、教授（2017）；
2016.03-2016.09：廣西科學(xué)技術(shù)廳（掛職），基礎(chǔ)研究處副處長；
2014.11-2015.11：英國牛津大學(xué)（University of Oxford），化學(xué)系，博士后（合作導(dǎo)師：Tom Brown 教授）；
2005.09-2010.12：湖南大學(xué)，化學(xué)生物傳感與計(jì)量學(xué)國家重點(diǎn)實(shí)驗(yàn)室，分析化學(xué)專業(yè)，獲理學(xué)博士學(xué)位（導(dǎo)師：吳海龍教授、俞汝勤院士）；
2001.09-2005.07：湖南大學(xué)，化學(xué)化工學(xué)院，應(yīng)用化學(xué)專業(yè)，獲理學(xué)學(xué)士學(xué)位（導(dǎo)師：吳海龍教授）。
（二）教學(xué)工作
本科生課程：《分析化學(xué)》、《計(jì)算機(jī)在分析化學(xué)中的應(yīng)用》、《環(huán)境分析化學(xué)》、《精細(xì)化學(xué)品化學(xué)》、《食品化學(xué)與分析》；研究生課程：《分子科學(xué)計(jì)算基礎(chǔ)》、《環(huán)境污染化學(xué)》。主持建設(shè)的《分析化學(xué)》中英文雙語在線開放課程于2018年5月在“學(xué)堂在線”主站平臺上線。目前，來自中國、美國、英國、意大利等世界各國的在線選課人數(shù)超過1.74萬（截至2019年5月）。
代表性教學(xué)/教改獲獎：
? 2018年度教育部在線研究中心“智慧教學(xué)之星”
? 桂林理工大學(xué)第十四屆十佳青年授課教師
? 桂林理工大學(xué)2013年度優(yōu)秀青年授課老師
? 第十一屆全國多媒體課件大賽優(yōu)秀獎
? 第十二屆全國多媒體課件大賽優(yōu)秀獎
? 第十二屆廣西區(qū)教育教學(xué)軟件大賽二等獎
? 第八屆廣西高校教學(xué)軟件大賽優(yōu)秀獎
? 桂林理工大學(xué)2013年首屆微課教學(xué)比賽二等獎
? 桂林理工大學(xué)第二屆多媒體教學(xué)軟件比賽二等獎
? 桂林理工大學(xué)第三屆多媒體教學(xué)軟件比賽二等獎
? 桂林理工大學(xué)“欣羽創(chuàng)新人才發(fā)展獎”
? 桂林理工大學(xué)2014年度優(yōu)秀班導(dǎo)師
指導(dǎo)本科生/研究生獲獎：
? 第12屆全國電分析化學(xué)學(xué)術(shù)會議論文墻展二等獎
? 2014年度廣西區(qū)優(yōu)秀碩士畢業(yè)生
? 2015年度廣西高校化學(xué)化工類論文及設(shè)計(jì)競賽一等獎
? 桂林市第二屆優(yōu)利特杯大學(xué)生科技創(chuàng)新設(shè)計(jì)大賽一等獎
? 桂林理工大學(xué)2014年度優(yōu)秀碩士畢業(yè)生
? 桂林理工大學(xué)2017年度優(yōu)秀碩士學(xué)位論文
（三）科研工作
主持國家自然科學(xué)基金項(xiàng)目3項(xiàng)、廣西重點(diǎn)研發(fā)計(jì)劃項(xiàng)目1項(xiàng)、廣西自然科學(xué)基金項(xiàng)目1項(xiàng)、廣西高等學(xué)校科研項(xiàng)目1項(xiàng)、桂林理工大學(xué)博士科研啟動基金項(xiàng)目1項(xiàng)。在Analytical Chemistry、Chemical Communications、Biosensors and Bioelectronics、Chemometrics and Intelligent Laboratory Systems、Journal of Chemometrics等分析化學(xué)領(lǐng)域國際主流期刊發(fā)表SCI收錄論文50余篇，其中影響因子大于4的期刊論文26篇、封底論文3篇。論文他引近1200篇次（單篇最高被引123次），個人H因子為20。研究成果被科技媒體X-MOL專題報道2次。作為主要成員參與譯著《化學(xué)計(jì)量學(xué)實(shí)用指南》。獲授權(quán)中國發(fā)明專利3項(xiàng)。
主持的科研項(xiàng)目：
? “基于靈敏調(diào)控紙潤濕性機(jī)制的重金屬免儀器快速定量檢測新方法研究”，國家自然科學(xué)基金項(xiàng)目，項(xiàng)目批準(zhǔn)號21765007，執(zhí)行年限2018-2021
? “基于雜交鏈?zhǔn)椒磻?yīng)和三階校正的轉(zhuǎn)錄因子高靈敏熒光檢測新方法研究”，國家自然科學(xué)基金項(xiàng)目，項(xiàng)目批準(zhǔn)號21565012，執(zhí)行年限2016-2019
? “基于圖案化紙和超疏水效應(yīng)抑制背景信號的核酸適配體生物分析新方法研究”，國家自然科學(xué)基金項(xiàng)目，項(xiàng)目批準(zhǔn)號21205021，執(zhí)行年限2013-2015
? “水環(huán)境重金屬免儀器快速定量檢測技術(shù)開發(fā)及應(yīng)用”，廣西重點(diǎn)研發(fā)計(jì)劃項(xiàng)目，項(xiàng)目編號桂科AB17129003，執(zhí)行年限2017-2020
? “多組分熒光免疫分析結(jié)合化學(xué)計(jì)量學(xué)方法用于生物體液中多項(xiàng)腫瘤標(biāo)記物的無干擾同時定量檢測”，廣西自然科學(xué)基金項(xiàng)目，項(xiàng)目批準(zhǔn)號2012GXNSFBA053029，執(zhí)行年限2012-2014
? “基于二階校正的三維熒光分析用于藥物與DNA的相互研究”，廣西高等學(xué)校科研項(xiàng)目，項(xiàng)目批準(zhǔn)號201203YB090，執(zhí)行年限2012-2014
? “復(fù)雜體系中多維數(shù)據(jù)解析的化學(xué)計(jì)量學(xué)方法研究”，桂林理工大學(xué)博士科研啟動基金項(xiàng)目，項(xiàng)目批準(zhǔn)號002401003337，執(zhí)行年限2011-2014
（四）主要學(xué)術(shù)與社會兼職
教育部學(xué)位與研究生教育發(fā)展中心學(xué)位論文評審專家；廣西發(fā)展戰(zhàn)略研究會專家；廣西科技計(jì)劃項(xiàng)目評審專家；2018年廣西職業(yè)院校信息化教學(xué)大賽評委；Journal of Chromatogrphy B、Applied Surface Science、Electrophoresis等國際SCI期刊審稿專家。
（五）代表性學(xué)術(shù)論文（*通訊作者）
1. Wencheng Xiao, Yiming Gao, Yun Zhang,* Jiao Li, Zhaoying Liu, Jinfang Nie,* Jianping Li. Enhanced 3D paper-based devices with a personal glucose meter for highly sensitive and portable biosensing of silver ion. Biosensors and Bioelectronics, 2019, 137, 154-160.
2. Haiyan Fu,* Qiaobo Yin, Huili Wang, Jinfang Nie, Wencheng Xiao, Zhaoying Liu, Yijing Chen, Yun Zhang.* Target-triggered in situ autocatalysis in nanopore membrane for point-of-care testing of sub-nanomolar Ag+. Sensors and Actuators: B. Chemical, 2019, 287, 290-295.
3. Jiao Li, Jie Xu, Wenying Jin, Zhongsheng Yi,* Chenbo Cai, Xuefen Huang, Jinfang Nie* and Yun Zhang. Fluorescent kinetics combined with fourth-order calibration for the determination of diclofenac sodium in environmental water. Analytical and Bioanalytical Chemistry, 2019, 411(10), 2019-2029.
4. Lang Zhang?, Yali Yuan?, Yun Zhang,* Zhaoying Liu, Wencheng Xiao, Jinfang Nie*, and Jianping Li. Equipment-Free Quantitative Aptamer-Based Colorimetric Assay Based on Target-Mediated Viscosity Change. ACS Omega, 2018, 3(2), 1451-1457.
5. 王兵月, 樂惠澤, 聶瑾芳,* 肖文成, 劉召應(yīng), 張?jiān)?/span>.* 基于目標(biāo)介導(dǎo)納米金凝集的Ag+目視檢測方法. 化學(xué)傳感器, 2018, 1, 48-54. 封面論文.
6. H. L. Wang, Y. Zhang,* R. X. Li, J. F. Nie,* A. H. El-Sagheer, T. Brown, Z. Y. Liu and W. C. Xiao. Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments. Chemical Communications, 2017, 53, 8407-8410. 封底論文.
7. J. H. Yang, Y. Zhang,* L. Zhang, H. L. Wang, J. F. Nie,* Z. X. Qin, J. Li and W. C. Xiao. Analyte-triggered autocatalytic amplification combined with gold nanoparticle probes for colorimetric detection of heavy-metal ions. Chemical Communications, 2017, 53, 7477-7480.
8. H.Y. Fu,* J.H. Yang, L. Guo, J.F. Nie,* Q.B. Yin, L. Zhang, Y. Zhang.* Using the Rubik's Cube to directly produce paper analytical devices for quantitative point-of-care aptamer-based assays. Biosensors and Bioelectronics, 2017, 96, 194-200.
9. S.W. Le, H. Zhou, J.F. Nie,* C.H. Cao, J.N. Yang,* H.C. Pan, J.P. Li and Y. Zhang.* Fabrication of paper devices via laser-heating-wax-printing for high-tech enzyme-linked immunosorbent assays with low-tech pen-type pH meter readout. Analyst, 2017, 142, 511-516.
10. L. Zhang, J.F. Nie,* H.L. Wang, J.H. Yang, B.Y. Wang, Y. Zhang* and J.P. Li. Instrument-free quantitative detection of alkaline phosphatase using paper-based devices. Analytical Methods, 2017, 9, 3375-3379
11. Nie J. F., Brown T., Zhang Y.* New two dimensional liquid-phase colorimetric assay based on old iodine–starch complexation for the naked-eye quantitative detection of analytes. Chemical Communications, 2016, 52: 7454-7457. 封底論文; 被X-MOL專題報道.
12. Zhang Y.,* Yang J. N., Nie J. F.,* Yang J. H., Gao D., Zhang L., Li J. P. Enhanced ELISA using a handheld pH meter and enzyme-coated microparticles for the portable, sensitive detection of proteins. Chemical Communications, 2016, 52: 3474-3477. 封底論文; 被X-MOL專題報道.
13. Zhang Y.,* Gao D., Fan J. L., Nie J. F.,* Le S. W., Zhu W. Y., Yang J. N., Li J. P. Naked-eye quantitative aptamer-based assay on paper device. Biosensors and Bioelectronics, 2016, 78: 538-546.
14. Nie J. F.,* Li B., Zhang Y.,* Fan J. L., Yi Z. S., Cai Z. R. High-order calibration for the spectrofluorimetric determination of pesticides based on photochemical derivatization. A solution of the problems of inner-filter effects and matrix interferences in complex environmental water. Chemometrics and Intelligent Laboratory Systems, 2016, 156: 36-53.
15. Zhang Y.,* Fan J. L., Nie J. F.,* Le S. W., Zhu W. Y., Gao D., Yang J. N., Zhang S. B., Li J. P. Timing readout in paper device for quantitative point-of-use hemin/G-quadruplex DNAzyme-based bioassays. Biosensors and Bioelectronics, 2015, 73: 13-18.
16. Zhang Y.,* Zhou C. B., Nie J. F.,* Le S. W., Qin Q., Liu F., Li Y. P. Equipment-free quantitative measurement for microfluidic paper-based analytical devices fabricated using the principles of movable-type printing. Analytical Chemistry, 2014, 86(4): 2005-2012.
17. Zhang Y.,* Liu F., Nie J. F.,* Jiang F. Y., Zhou C. B., Yang J. N., Fan J. L., Li J. P. An electrochemical sensing platform based on local repression of electrolyte diffusion for single-step, reagentless, sensitive detection of a sequencespecific DNA-binding protein. Analyst, 2014, 139(9): 2193-2198.
18. Nie J. F., Liang Y. Z., Zhang Y.,* Le S. W., Li D. N., Zhang S. B. One-step patterning of hollow microstructures in paper by laser cutting to create microfluidic analytical devices. Analyst, 2013, 138(2): 671-676.
19. Nie J. F., Zhang Y.,* Lin L. W., Zhou C. B., Li S. H., Zhang L. M., Li J. P. Low-cost fabrication of paper-based microfluidic devices by one-step plotting. Analytical Chemistry, 2012, 84(15): 6331-6335.
20. Nie J. F., Zhang Y.,* Wang H., Wang S. P., Shen G. L. Superhydrophobic surface-based magnetic electrochemical immunoassay for detection of Schistosoma japonicum antibodies. Biosensors and Bioelectronics, 2012, 33(1): 23-28.
21. Nie J. F., Zhang Y.,* Yi Z. S., Zou H. Y., Fu H. Y., Wu H. L. Advanced chemometric algorithm coupled to subspace projection technique between original and pseudo samples: A snapshot of chemical rank estimation for high-order data. Chemometrics and Intelligent Laboratory Systems, 2012, 118: 211-218.
22. Shao S. Z., Wu H. L.,* Li S. F., Nie J. F., Wang K. Y., Liang Y., Yu R. Y. Determination of levodopa in both human Urine and plasma samples using excitation–emission matrix fluorescence coupled with second-order calibration. Journal of Analytical Science, 2012, 24: 373-378.
23. Zhang Y., Wang H.,* Li J. P., Nie J. F., Zhang Y. W, Shen G. L.,* Yu. R. Q. Nitrocellulose strip array assembled on superhydrophobic surface: An aqueous solution diffusion-localized platform for multianalyte immunogold staining assays. Biosensors and Bioelectronics, 2011, 26 (7): 3272-3277.
24. 聶瑾芳, 吳海龍*, 張?jiān)?/span>, 劉亞娟, 王建瑤, 李勇, 俞汝勤. 三線性分解方法用于激發(fā)-發(fā)射矩陣熒光數(shù)據(jù)中一階瑞利散射的扣除. 中國科學(xué): 化學(xué), 2011 , 41(11): 1740-1749.
25. Fu H. Y., Wu H. L.*, Yu Y. J., Yu L. L., Zhang S. R., Nie J. F., Li S. F., Yu R. Q. A new third-order calibration method with application for analysis of four-way data arrays. Journal of Chemometrics, 2011, 25: 408-429.
26. Yu Y. J., Wu H. L.*, Nie J. F., Zhang S. R., Li S. F., Li Y. N., Zhu S. H., Yu R. Q. A comparison of several trilinear second-order calibration algorithms. Chemometrics and Intelligent Laboratory Systems, 2011, 106: 93-107.
27. Liu Y. J., Wu H. L.,* Kang C., Gu H. W., Nie J. F., Li S. S., Su Z. Y., Yu R. Q. Four-way self-weighted alternating normalized residue fitting algorithm with application for the analysis of serotonin in human plasma. Analytical Sciences, 2011, 28(11): 1097-1104.
28. Nie J. F., Wu H. L.,* Wang J. Y., Liu Y. J., Yu. R. Q. Chemical rank estimation for excitation-emission matrix fluorescence data by region-based moving window subspace projection technique and Monte Carlo simulation. Chemometrics and Intelligent Laboratory Systems, 2010, 104: 271-280.
29. Nie J. F., Wu H. L.*, Zhang S. R., Yu Y. J., Yu R. Q. Self-weighted alternating normalized residue fitting algorithm with application to quantitative analysis of excitation-emission matrix fluorescence data. Analytical Methods, 2010, 2: 1918-1926.
30. Li S. F., Wu H. L.*, Yu Y. J., Li Y. N., Nie J. F., Fu H. Y., Yu R. Q. Quantitative analysis of levodopa, carbidopa and methyldopa in human plasma samples using HPLC-DAD combined with second-order calibration based on alternating trilinear decomposition algorithm. Talanta, 2010, 81: 805-812.
31. Cai C. B., Xu L., Han Q. J., Wu H. L., Nie J. F., Fu H. Y., Yu R. Q.* Combining the least correlation design, wavelet packet transform and correlation coefficient test to reduce the size of calibration set for NIR quantitative analysis in multi-component systems. Talanta, 2010, 81: 799-804.
32. Zou H. Y., Wu H. L.*, Fu H. Y., Tang L. J., Xu L., Nie J. F., Yu R. Q. Variable-weighted least-squares support vector machine for multivariate spectral analysis. Talanta, 2010, 80: 1698-1701.
33. Zou H. Y., Wu H. L.,* Li Y. N., Nie J. F., Fu H. Y., Li S. F., Ouyang L. Q., Yu R. Q. Simultaneous determination of dextromethorphan and quinidine in biological fluids by excitation-emission matrix fluorescence coupled with second-order calibration methods. Analytical Letters, 2010, 43, 2739-2750.
34. Li S. F., Wu H. L.,* Huang L., Li Y. N., Nie J. F., Zhang S. R., Yu R. Q. Quantitative analysis of fluphenazine hydrochloride in human urine samples using excitation-emission matrix fluorescence based on oxidation derivation and combined with second-order calibration methods. Analytical Methods, 2010, 2, 1069-1077.
35. Fu H. Y., Wu H. L.,* Zou H. Y., Tang L. J., Xu L, Cai C. B., Nie J. F., Yu R. Q. Automatic configuration of optimized sample-weighted least-squares support vector machine by particle swarm optimization for multivariate spectral analysis. Analytical Methods, 2010, 2: 282-288.
36. Fu H. Y., Wu H. L.,* Nie J. F., Yu Y. J., Zou H.Y., Yu R. Q. Highly sensitive fluorescence quantification of irinotecan in biological fluids with the aid of second-order advantage. Chinese Chemical Letters, 2010, 21(12): 1482-1486.
37. Zhang Y., Wang H.,* Nie J. F., Zhang Y. W., Shen G. L.,* Yu. R. Q. Individually addressable microelectrode arrays fabricated with gold-coated pencil graphite particles for multiplexed and high sensitive impedance immunoassays. Biosensors and Bioelectronics, 2009, 25(1): 34-40.
38. Wu H. L.*, Nie J. F., Yu Y. J., Yu. R. Q. Multi-way chemometric methodologies and applications: A central summary of our research work (邀請綜述). Analytica Chimica Acta, 2009, 650: 131-142.
39. Zhang Y., Wang H.,* Nie J. F., Zhou H., Shen G. L.*, Yu R. Q. Mussel-inspired fabrication of encoded polymer films for electrochemical identification. Electrochemistry Communication, 2009, 11: 1936-1939.
40. OuYang L. Q., Wu H. L.*, Nie J. F., Zhang Y., Zou H. Y., Fu H. Y., Yu R. Q. Simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine Xian Ling Gu Bao capsule by using HPLC-DAD coupled with alternating trilinear decomposition algorithm. Analytica Chimica Acta, 2009, 650: 160-166.
41. Zou H. Y., Wu H. L.*, OuYang L. Q., Zhang Y., Nie J. F., Fu H. Y., Yu R. Q. Fluorescent quantification of terazosin hydrochloride content in human plasma and tablets using second-order calibration based on both parallel factor analysis and alternating penalty trilinear decomposition. Analytica Chimica Acta, 2009, 650: 143-149.
42. Zhu S. H., Wu H. L.*, Xia A. L., Nie J. F., Bian Y. C., Cai C. B., Yu R. Q, Excitation-emission-kinetic fluorescence coupled with third-order calibration for quantifying carbaryl and investigating the hydrolysis in effluent water. Talanta, 2009, 77: 1640-1646.
43. Wang X. M., Wu H. L.,* Nie J. F., Yu R. Q. Rapid determination of bitertanol content in banana using three-dimensional fluorescence coupled with second-order calibration. Chinese Journal of Analytical Chemistry, 2009, 37: 811-816.
44. Li Y. N., Wu H. L.,* Nie J. F., Li S. F., Yu Y. J., Zhang S. R., Yu R. Q. Interference-free determination of abscisic acid and gibberellin in plant samples by using excitation-emission matrix fluorescence based on oxidation derivatization coupled with second-order calibration methods. Analytical Methods, 2009, 1: 115-122.
45. Li Y. N., Wu H. L.,* Zhang S. R., Nie J. F., Yu Y. J., Wang X. M., Yu R. Q. Determination of indole-3-Acetic acid in soil using excitation-emission matrix fluorescence with trilinear decomposition-based calibration methods. Analytical Sciences, 2009, 25: 83-88.
46. Zou H. Y., Wu H. L.,* Zhang Y., Li S. F., Nie J. F., Fu H. Y., Yu R. Q. Studying the interaction of pirarubicin with DNA and determining pirarubicin in human urine samples: Combining excitation-emission fluorescence matrices with second-order calibration methods. Journal of Fluorescence, 2009, 6: 955-966.
47. Li S. F., Wu H. L.,* Xia A L., Zhu S. H., Nie J. F., Yu R. J., Yu R. Q. Quantitative analysis of epinephrine in human plasma samples using kinetic fluorometric method combined with second-order calibration. Analytical Sciences, 2009, 25: 1231-1236.
48. Nie J. F., Wu H. L.*, Wang X. M., Zhang Y., Zhu S. H., Yu R. Q. Determination of testosterone propionate in cosmetics using excitation-emission matrix fluorescence based on oxidation derivatization with the aid of second-order calibration methods. Analytica Chimica Acta, 2008, 628: 24-32.
49. Nie J. F., Wu H. L.*, Zhu S. H., Han Q. J., Fu H. Y., Li S. F., Yu R. Q. Simultaneous determination of 6-methylcoumarin and 7-methoxycoumarin in cosmetics using three-dimensional excitation–emission matrix fluorescence coupled with second-order calibration methods. Talanta, 2008, 75: 1260-1269.
50. Cai C. B., Han Q. J., Tang L. J., Nie J. F., OuYang L. Q., Yu R. Q.* Treating NIR data with orthogonal discrete wavelet transform: Predicting concentrations of a multi-component system through a small-scale calibration set. Talanta, 2008, 77: 822-826.
51. Wang X. M., Wu H. L.*, Nie J. F., Li Y. N., Yu Y. J., Yu R. Q. Rapid determination of thiabendazole in orange extract using excitation-emission matrix fluorescence and second-order calibration based on alternating trilinear decomposition/alternating normalization-weighted error algorithms. Science in China, Series B: Chemistry, 2008, 51: 729-735.
52. 王雪梅, 吳海龍*, 聶瑾芳, 李元娜, 于永杰, 俞汝勤. 激發(fā)發(fā)射熒光二階張量校正算法快速檢測桔子中噻苯咪唑. 中國科學(xué)B, 2008, 38: 288-293.
53. Han Q. J., Wu H. L.,* Nie J. F., Xia A L., Zhu S. H., Yu R. Q. Direct determination of reserpine in urine using excitation-emission fluorescence combined with three-way chemometric calibration methodologies. Frontiers of Chemistry in China-Selected Publications from Chinese Universities, 2008, 3: 224-228.
54. Wang X. M., Wu H. L.,* Nie J. F., Li Y. N., Yu Y. J., Yu R. Q. Rapid determination of thiabendazole in orange extract using excitation-emission matrix fluorescence and second-order calibration based on alternating trilinear decomposition/alternating normalization-weighted error algorithms. Science in China, Series B: Chemistry, 2008, 51: 729-735.
55. Nie J. F., Wu H. L.*, Xia A. L., Zhu S. H., Bian Y. C., Li S. F., Yu R. Q., Determination of sulpiride in human urine using excitation-emission matrix fluorescence coupled with second-order calibration. Analytical Sciences, 2007, 23: 1377-1382.
